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An article published on The American Journal on Addictions stated that women that are pregnant who were addicted to opioids were strongly considering antagonist treatment, especially the one which involves the using naltrexone to combat their substance abuse disorder. Using two separate drugs to shed pounds can be very effective you can find combinations before the FDA now awaiting approval. When dealing with fat loss and the people that go through it you need to err to the side of caution and let the FDA do its job and demand some investigation be done so the public recognizes the side effects and hazards of the medications before we drive them. Keep in mind that drug companies have been in business to earn money and that they would say anything to keep people on their own medications. Researchers found out that participants investing in this drug to get a year, dropped excess weight within four weeks and have kept the extra weight off through the 56 weeks with the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of more than one active ingredient, which might make them more effective and safer. Combo-pilling may be the newest fad or even better the newest to come under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is becoming popular will be the fact that as of right now there are not any long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise hypertension and heartrate, and shouldn't be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must stop used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients using a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients to the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking. From a psychiatric standpoint, evidence implies that the ordinary neural mechanism for goal-directed behavior has been hijacked by the addiction, and malfunctions so that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus and the person engages in a "goal-directed behavioral response" that produces a "natural high"(Bostwick & Bucci, 2008).